Phytochemical Compositions, Nutritional Contents, Cytotoxicity and Anti-Inflammatory Activity of Different Extracts from Spirogyra neglecta (Hassall) Kützing

Spirogyra neglecta (Hassall) Kützing is an edible freshwater macroalga. It available and consumed as local food in Thailand, especially the northern northeastern parts. To ascertain its good benefit for health safe consumption, this study was, therefore carried out to determine phytochemical compositions, nutritional contents, cytotoxicity, anti-inflammatory activity of different extracts from S. neglecta. The were prepared by using solvents, such propylene glycol, methanol, ethanol solutions. GC-MS analysis revealed presence 30, 39 36 compounds extracts, respectively. Phytol, which has been reported have activity, was one predominant compositions extracts. contained high contents protein, lipid, fiber, ash, moisture, carbohydrate up 21.68 ± 4.52, 3.53 0.23, 14.77 0.89, 10.73 0.47, 9.79 0.11 47.36 3.89 %, highest total protein found glycol extract. lipid Meanwhile, ash methanol In addition, all possess relatively low with IC50 values greater than 1,000 µg/mL. µg/mL exhibited via inhibition Nitric oxide (NO) production 29.87 1.56 55.17 1.91 %. showed inhibitory on NO compared others. overall results indicating solvent that produces best extraction performance. exhibit inhibiting production. are partly responsible complement toxic. Thus, can be used natural sources products, supplements, medicinal plants. HIGHLIGHTS Using analysis, there neglecta, respectively show toxic RAW 246.7 cells LC50 >1,000 µg/mL, MTT assay extract displays others partially Phytol GRAPHICAL ABSTRACT